Shep is right, EFI is technically superior, but takes a lot of time to learn to tune. For example, if you think you can pop into the Tweecer the night UPS brings it and set your timing back 6 degrees at 1500 RPM, you are mistaken. There are probably 5 or 6 settings that control timing in the ECC -- all related and interact with one another. On the flip side, once you learn it, you can go in and set the timing exactly where you want it. Several members of the tweecer forum mentioned that they have been working on their tune for two years or more. (I suspect many people buy the Tweecer for its geek factor, rather than actually trying to make the car run better.)
Support for the Tweecer is pretty much nonexistent and there has not been a new release from STKR in a few years.
To my knowledge, Ford has also never officially released any documentation for its EFI systems, any Ford docs you see on the net were "borrowed". People figured out how it works by hacking into the computer, so you will probably never get a fully correct/complete answer to any questions you may have. Go to the Tweecer website and get the GUFB document, read thru it to see if its something that you want to tackle.
My take...
1. Supercharger or Turbo -- EFI no question, AEM computer.
2. Stock or very mild Engine - stock EFI, limited tuning required, a chip only at the most. Can probably get a decent tune thru mail order.
3. mid-level engine - EFI tuned by a pro, Tweecer if you want to devote time to it. Carb.
4. Radical Engine - Carb, AEM computer tuned by a pro
Don't get me wrong. I am a fan of EFI, my car had a radical engine with EFI, no matter what we did, we could not tune out the bucking. I worked offline with several members from the Tweecer forum and local folks for several months, no joy. In the interests of getting my car done, I switched over to carb, dropped the carb on, it started right up (and has every time since) no bucking, no problems out of the box. (Now about that dual quad setup....

)
The carb looks more period correct, but now my car needs a few minutes to warm up before driving off -- with a properly tuned EFI setup its start and go. Will dyno this weekend.
Ouch, soory to be so long winded.
Tony